Alpha Thalassemia/Mental Retardation Syndrome X-linked Gene Product ATRX Is Required for Proper Replication Restart and Cellular Resistance to Replication Stress

Alpha thalassemia/mental retardation syndrome X-linked (ATRX) is a member of the SWI/SNF protein family of DNA-dependent ATPases. It functions as a chromatin remodeler and is classified as an SNF2-like helicase. Here, we showed somatic knock-out of ATRX displayed perturbed S-phase progression as wel...

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Bibliographic Details
Main Authors: Leung, Justin Wai-Chung, Ghosal, Gargi, Wang, Wenqi, Shen, Xi, Wang, Jiadong, Li, Lei, Chen, Junjie
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585069/
https://ncbi.nlm.nih.gov/pubmed/23329831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.411603
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