SCF(Fbxw15) Mediates Histone Acetyltransferase Binding to Origin Recognition Complex (HBO1) Ubiquitin-Proteasomal Degradation to Regulate Cell Proliferation

Histone acetyltransferase binding to origin recognition complex (HBO1) plays a crucial role in DNA replication licensing and cell proliferation, yet its molecular regulation in cells is relatively unknown. Here an uncharacterized protein, Fbxw15, directly interacts with HBO1, a labile protein (t(½)...

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Bibliographic Details
Main Authors: Zou, Chunbin, Chen, Yan, Smith, Rebecca M., Snavely, Courtney, Li, Jin, Coon, Tiffany A., Chen, Bill B., Zhao, Yutong, Mallampalli, Rama K.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585065/
https://ncbi.nlm.nih.gov/pubmed/23319590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.426882
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