Cell Reprogramming Requires Silencing of a Core Subset of Polycomb Targets

Transcription factor (TF)–induced reprogramming of somatic cells into induced pluripotent stem cells (iPSC) is associated with genome-wide changes in chromatin modifications. Polycomb-mediated histone H3 lysine-27 trimethylation (H3K27me3) has been proposed as a defining mark that distinguishes the...

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Detalhes bibliográficos
Main Authors: Fragola, Giulia, Germain, Pierre-Luc, Laise, Pasquale, Cuomo, Alessandro, Blasimme, Alessandro, Gross, Fridolin, Signaroldi, Elena, Bucci, Gabriele, Sommer, Cesar, Pruneri, Giancarlo, Mazzarol, Giovanni, Bonaldi, Tiziana, Mostoslavsky, Gustavo, Casola, Stefano, Testa, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585017/
https://ncbi.nlm.nih.gov/pubmed/23468641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003292
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