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Reflection on design and testing of pancreatic alpha-amylase inhibitors: an in silico comparison between rat and rabbit enzyme models

BACKGROUND: Inhibitors of pancreatic alpha-amylase are potential drugs to treat diabetes and obesity. In order to find compounds that would be effective amylase inhibitors, in vitro and in vivo models are usually used. The accuracy of models is limited, but these tools are nonetheless valuable. In v...

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Detalhes bibliográficos
Main Authors: Khalil-Moghaddam, Shiva, Ebrahim-Habibi, Azadeh, Pasalar, Parvin, Yaghmaei, Parichehreh, Hayati-Roodbari, Nasim
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584935/
https://ncbi.nlm.nih.gov/pubmed/23352052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2008-2231-20-77
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