FMRP Regulates Neurotransmitter Release and Synaptic Information Transmission by Modulating Action Potential Duration via BK channels

Loss of FMRP causes Fragile X syndrome (FXS), but the physiological functions of FMRP remain highly debatable. Here we show that FMRP regulates neurotransmitter release in CA3 pyramidal neurons by modulating action potential (AP) duration. Loss of FMRP leads to excessive AP broadening during repetit...

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Библиографические подробности
Главные авторы: Deng, Pan-Yue, Rotman, Ziv, Blundon, Jay A., Cho, Yongcheol, Cui, Jianmin, Cavalli, Valeria, Zakharenko, Stanislav S., Klyachko, Vitaly A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584349/
https://ncbi.nlm.nih.gov/pubmed/23439122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.12.018
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