Polymorphic Expression of UDP-Glucuronosyltransferase UGTlA Gene in Human Colorectal Cancer

BACKGROUND: Polymorphism of genes encoding drug-metabolizing enzymes is known to play an important role in increased susceptibility of colorectal cancer. UGT1A gene locus has been suggested to define tissue-specific glucuronidation activity. Reduced capacity of glucuronidation is correlated with the...

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Main Authors: Wang, Min, Sun, De-Feng, Wang, Shuai, Qing, Ying, Chen, Shuo, Wu, Dong, Lin, Ying-Min, Luo, Ji-Zhuang, Li, Yan-Qing
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584141/
https://ncbi.nlm.nih.gov/pubmed/23468910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057045
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