Dominant negative retinoid X receptor beta inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells.

Retinoid X receptors (RXRs) heterodimerize with multiple nuclear hormone receptors and are thought to exert pleiotropic functions. To address the role of RXRs in retinoic acid- (RA) mediated gene regulation, we designed a dominant negative RXR beta. This mutated receptor, termed DBD-, lacked the DNA...

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Autores principales: Minucci, S, Zand, D J, Dey, A, Marks, M S, Nagata, T, Grippo, J F, Ozato, K
Formato: Artigo
Lenguaje:Inglês
Publicado: 1994
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC358385/
https://ncbi.nlm.nih.gov/pubmed/8264603
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