Identification of active Plasmodium falciparum calpain to establish screening system for Pf-calpain-based drug development

BACKGROUND: With the increasing resistance of malaria parasites to available drugs, there is an urgent demand to develop new anti-malarial drugs. Calpain inhibitor, ALLN, is proposed to inhibit parasite proliferation by suppressing haemoglobin degradation. This provides Plasmodium calpain as a poten...

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Bibliografski detalji
Glavni autori: Soh, Byoung Yul, Song, Hyun-Ok, Lee, Yoonji, Lee, Junghyun, Kaewintajuk, Kusuma, Lee, Binna, Choi, Yun-Young, Cho, Jeong Hoon, Choi, Sun, Park, Hyun
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583800/
https://ncbi.nlm.nih.gov/pubmed/23374507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-12-47
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