Association of epigenetic inactivation of the WRN gene with anticancer drug sensitivity in cervical cancer cells

The Werner (WRN) gene codes for a DNA helicase that contributes to genomic stability and has been identified as the gene responsible for progeria. Recent studies have shown reduced WRN expression due to aberrant DNA hypermethylation in cancer cells. Furthermore, WRN expression is thought to affect s...

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Main Authors: MASUDA, KENTA, BANNO, KOUJI, YANOKURA, MEGUMI, TSUJI, KOSUKE, KOBAYASHI, YUSUKE, KISU, IORI, UEKI, ARISA, YAMAGAMI, WATARU, NOMURA, HIROYUKI, TOMINAGA, EIICHIRO, SUSUMU, NOBUYUKI, AOKI, DAISUKE
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583574/
https://ncbi.nlm.nih.gov/pubmed/22797812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2012.1912
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