Release of Plasmid DNA-Encoding IL-10 from PLGA Microparticles Facilitates Long-Term Reversal of Neuropathic Pain Following a Single Intrathecal Administration

PURPOSE: Interleukin-10 (IL-10) is an anti-inflammatory molecule that has achieved interest as a therapeutic for neuropathic pain. In this work, the potential of plasmid DNA-encoding IL-10 (pDNA-IL-10) slowly released from biodegradable microparticles to provide long-term pain relief in an animal mo...

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Hauptverfasser: Soderquist, Ryan Gene, Sloane, Evan M., Loram, Lisa C., Harrison, Jacqueline A., Dengler, Ellen C., Johnson, Scott M., Amer, Luke D., Young, Courtney S., Lewis, Makenzie T., Poole, Stephen, Frank, Matthew G., Watkins, Linda R., Milligan, Erin D., Mahoney, Melissa J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583569/
https://ncbi.nlm.nih.gov/pubmed/20224990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-010-0077-y
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