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Camptothecin nanocolloids based on N,N,N-trimethyl chitosan: Efficient suppression of growth of multiple myeloma in a murine model

Camptothecin (CPT) exhibits very strong antitumor effects by inhibiting the activity of DNA topoisomerase I, but its application is greatly limited due to its low solubility and the instability of the active lactone form. To overcome these shortcomings, in the present study, we prepared novel campto...

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Bibliografske podrobnosti
Main Authors: LI, ZHENGGUANG, LI, XINGYI, CAO, ZHIXING, XU, YOUZHI, LIN, HONGJUN, ZHAO, YINGLAN, WEI, YUQUAN, QIAN, ZHIYONG
Format: Artigo
Jezik:Inglês
Izdano: D.A. Spandidos 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583474/
https://ncbi.nlm.nih.gov/pubmed/22245938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2012.1635
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