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Resistance to PARP-Inhibitors in Cancer Therapy

The pharmacological inhibitors of poly(ADP-ribose) polymerase (PARP) family of proteins have shown promising results in preclinical studies and clinical trials as a monotherapy or in combination therapy for some cancers. Thus, usage of PARP-inhibitors (PARPi) in cancer therapy is bound to increase w...

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Detalhes bibliográficos
Main Authors: Montoni, Alicia, Robu, Mihaela, Pouliot, Émilie, Shah, Girish M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583007/
https://ncbi.nlm.nih.gov/pubmed/23450678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2013.00018
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