Human APOBEC3G-mediated hypermutation is associated with antiretroviral therapy failure in HIV-1 subtype C-infected individuals

INTRODUCTION: Human APOBEC3G/F (hA3G/F) restricts retroviral replication through G-to-A hypermutations, which can generate drug-resistant progenies in vitro. The clinical relevance is still inconclusive. To bridge this gap, we aim to study the role of these hypermutations in evolution of drug resist...

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Main Authors: Neogi, Ujjwal, Shet, Anita, Sahoo, Pravat Nalini, Bontell, Irene, Ekstrand, Maria L, Banerjea, Akhil C, Sonnerborg, Anders
Format: Artigo
Sprog:Inglês
Udgivet: International AIDS Society 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582697/
https://ncbi.nlm.nih.gov/pubmed/23443042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7448/IAS.16.1.18472
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