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Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms
α(2)-Macroglobulin (α(2)M) is an extracellular chaperone that inhibits amorphous and fibrillar protein aggregation. The reaction of α(2)M with proteases results in an ‘activated’ conformation, where the proteases become covalently-linked within the interior of a cage-like structure formed by α(2)M....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier Science B.V
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3581772/ https://ncbi.nlm.nih.gov/pubmed/23353684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.01.020 |
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