Interleukin-20 Promotes Migration of Bladder Cancer Cells through Extracellular Signal-regulated Kinase (ERK)-mediated MMP-9 Protein Expression Leading to Nuclear Factor (NF-κB) Activation by Inducing the Up-regulation of p21(WAF1) Protein Expression

The role of inflammatory cytokine interleukin-20 (IL-20) has not yet been studied in cancer biology. Here, we demonstrated up-regulation of both IL-20 and IL-20R1 in muscle-invasive bladder cancer patients. The expressions of IL-20 and IL-20R1 were observed in bladder cancer 5637 and T-24 cells. We...

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Main Authors: Lee, Se-Jung, Cho, Seok-Cheol, Lee, Eo-Jin, Kim, Sangtae, Lee, Soo-Bok, Lim, Jung-Hyurk, Choi, Yung Hyun, Kim, Wun-Jae, Moon, Sung-Kwon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581371/
https://ncbi.nlm.nih.gov/pubmed/23271730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.410233
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