Direct Observation of Aminoglycoside–RNA Binding by Localized Surface Plasmon Resonance (LSPR) Spectroscopy

RNA is involved in fundamental biological functions when bacterial pathogens replicate. Identifying and studying small molecules that can interact with bacterial RNA and interrupt cellular activities is a promising path for drug design. Aminoglycoside (AMG) antibiotics, prominent natural products th...

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Bibliographic Details
Main Authors: Frolov, Ludmila, Dix, Andrew, Tor, Yitzhak, Tesler, Alexander B., Chaikin, Yulia, Vaskevich, Alexander, Rubinstein, Israel
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581361/
https://ncbi.nlm.nih.gov/pubmed/23368968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac3029079
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