Obstructive Sleep Apnoea Syndrome and Weight Loss: Review

Obstructive sleep apnoea (OSA) syndrome is common, and obesity is a major risk factor. Increased peripharyngeal and central adiposity result in increased pharyngeal collapsibility, through increased mechanical loading around the upper airway, reduced tracheal traction on the pharynx, and reduced neu...

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Main Authors:	Cowan, Douglas C., Livingston, Eric
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Hindawi Publishing Corporation 2012
Assuntos:	Review Article
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3581237/ https://ncbi.nlm.nih.gov/pubmed/23471145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/163296
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id	pubmed-3581237
record_format	dspace
spelling	pubmed-35812372013-03-06 Obstructive Sleep Apnoea Syndrome and Weight Loss: Review Cowan, Douglas C. Livingston, Eric Sleep Disord Review Article Obstructive sleep apnoea (OSA) syndrome is common, and obesity is a major risk factor. Increased peripharyngeal and central adiposity result in increased pharyngeal collapsibility, through increased mechanical loading around the upper airway, reduced tracheal traction on the pharynx, and reduced neuromuscular activity, particularly during sleep. Significant and sustained weight loss, if achieved, is likely to be a useful therapeutic option in the management of OSA and may be attempted by behavioural, pharmacological, and surgical approaches. Behavioural therapy programs that focus on aspects such as dietary intervention, exercise prescription patients and general lifestyle counselling have been tested. Bariatric surgery is an option in the severely obese when nonsurgical measures have failed, and laparoscopic adjustable gastric banding and Roux-en-Y gastric bypass are the most commonly employed techniques in the United Kingdom. Most evidence for efficacy of surgery comes from cohort studies. The role of sibutramine in OSA in the obese patients has been investigated, however, there are concerns regarding associated cardiovascular risk. In this paper the links between obesity and OSA are discussed, and the recent studies evaluating the behavioural, pharmacological and surgical approaches to weight loss in OSA are reviewed. Hindawi Publishing Corporation 2012 2012-01-23 /pmc/articles/PMC3581237/ /pubmed/23471145 http://dx.doi.org/10.1155/2012/163296 Text en Copyright © 2012 D. C. Cowan and E. Livingston. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
institution	US NLM
collection	PubMed Central
language	Inglês
format	Artigo
topic	Review Article
spellingShingle	Review Article Cowan, Douglas C. Livingston, Eric Obstructive Sleep Apnoea Syndrome and Weight Loss: Review
description	Obstructive sleep apnoea (OSA) syndrome is common, and obesity is a major risk factor. Increased peripharyngeal and central adiposity result in increased pharyngeal collapsibility, through increased mechanical loading around the upper airway, reduced tracheal traction on the pharynx, and reduced neuromuscular activity, particularly during sleep. Significant and sustained weight loss, if achieved, is likely to be a useful therapeutic option in the management of OSA and may be attempted by behavioural, pharmacological, and surgical approaches. Behavioural therapy programs that focus on aspects such as dietary intervention, exercise prescription patients and general lifestyle counselling have been tested. Bariatric surgery is an option in the severely obese when nonsurgical measures have failed, and laparoscopic adjustable gastric banding and Roux-en-Y gastric bypass are the most commonly employed techniques in the United Kingdom. Most evidence for efficacy of surgery comes from cohort studies. The role of sibutramine in OSA in the obese patients has been investigated, however, there are concerns regarding associated cardiovascular risk. In this paper the links between obesity and OSA are discussed, and the recent studies evaluating the behavioural, pharmacological and surgical approaches to weight loss in OSA are reviewed.
author	Cowan, Douglas C. Livingston, Eric
author_facet	Cowan, Douglas C. Livingston, Eric
author_sort	Cowan, Douglas C.
title	Obstructive Sleep Apnoea Syndrome and Weight Loss: Review
title_short	Obstructive Sleep Apnoea Syndrome and Weight Loss: Review
title_full	Obstructive Sleep Apnoea Syndrome and Weight Loss: Review
title_fullStr	Obstructive Sleep Apnoea Syndrome and Weight Loss: Review
title_full_unstemmed	Obstructive Sleep Apnoea Syndrome and Weight Loss: Review
title_sort	obstructive sleep apnoea syndrome and weight loss: review
publisher	Hindawi Publishing Corporation
publishDate	2012
url	https://ncbi.nlm.nih.gov/pmc/articles/PMC3581237/ https://ncbi.nlm.nih.gov/pubmed/23471145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/163296
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Obstructive Sleep Apnoea Syndrome and Weight Loss: Review

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