Local Autoantigen Expression as Essential Gatekeeper of Memory T-Cell Recruitment to Islet Grafts in Diabetic Hosts

It is generally believed that inflammatory cues can attract noncognate, “bystander” T-cell specificities to sites of inflammation. We have shown that recruitment of naive and in vitro activated autoreactive CD8(+) T cells into endogenous islets requires local autoantigen expression. Here, we demonst...

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Autors principals: Alkemade, Gonnie M., Clemente-Casares, Xavier, Yu, Zhenguo, Xu, Bao-You, Wang, Jinguo, Tsai, Sue, Wright, James R., Roep, Bart O., Santamaria, Pere
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2013
Matèries:
Immunology and Transplantation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581210/
https://ncbi.nlm.nih.gov/pubmed/23160528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0600
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