Th17 expansion in granulomatosis with polyangiitis (Wegener's): the role of disease activity, immune regulation and therapy

INTRODUCTION: In autoimmune diseases, IL-17 producing T-cells (Th17), a pro-inflammatory subset of T-cells, are pathophysiologically involved. There is little knowledge on the role of Th17 cells in granulomatosis with polyangiitis (GPA). In the present study, we investigated Th17 cells, Tregs and su...

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Bibliographic Details
Main Authors: Wilde, Benjamin, Thewissen, Marielle, Damoiseaux, Jan, Hilhorst, Marc, van Paassen, Pieter, Witzke, Oliver, Cohen Tervaert, Jan Willem
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580538/
https://ncbi.nlm.nih.gov/pubmed/23079279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4066
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