Secretome analysis of chondroitin sulfate-treated chondrocytes reveals anti-angiogenic, anti-inflammatory and anti-catabolic properties

INTRODUCTION: Chondroitin sulfate (CS) is a symptomatic slow-acting drug for osteoarthritis (OA) widely used in the clinic. The aim of this work is to find proteins whose secretion from cartilage cells under proinflammatory stimuli (IL-1β) is regulated by CS, employing a novel quantitative proteomic...

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Main Authors: Calamia, Valentina, Lourido, Lucía, Fernández-Puente, Patricia, Mateos, Jesús, Rocha, Beatriz, Montell, Eulalia, Vergés, Josep, Ruiz-Romero, Cristina, Blanco, Francisco J
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580514/
https://ncbi.nlm.nih.gov/pubmed/23031212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4040
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