Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-β in ARPE-19

AIM: To investigate the role of Rho-associated protein kinase (ROCK) inhibitor, Y27632, in mediating the production of extracellular matrix (ECM) components including fibronectin, matrix metallo-proteinase-2 (MMP-2) and type I collagen as induced by connective tissue growth factor (CTGF) or transfor...

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Autors principals: Zhu, Jing, Nguyen, Duy, Ouyang, Hong, Zhang, Xiao-Hui, Chen, Xiao-Ming, Zhang, Kang
Format: Artigo
Idioma:Inglês
Publicat: International Journal of Ophthalmology Press 2013
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580241/
https://ncbi.nlm.nih.gov/pubmed/23550216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3980/j.issn.2222-3959.2013.01.02
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