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Wiskott-Aldrich Syndrome at the nexus of autoimmune and primary immunodeficiency diseases

Wiskott-Aldrich Syndrome (WAS) is a X-linked primary immunodeficiency disorder also marked by a very high (up to 70%) incidence of autoimmunity. Wiskott-Aldrich Syndrome arises from mutations in the Wiskott-Aldrich Syndrome protein (WASp), a cytoplasmic protein that links signaling by cell surface r...

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Autori principali: Cleland, Sophia Y., Siegel, Richard M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580218/
https://ncbi.nlm.nih.gov/pubmed/22036785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2011.10.031
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