Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma

Recent sequencing efforts have described the mutational landscape of the pediatric brain tumor medulloblastoma. Although MLL2 is among the most frequent somatic single nucleotide variants (SNV), the clinical and biological significance of these mutations remains uncharacterized. Through targeted re-...

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Main Authors: Dubuc, Adrian M., Remke, Marc, Korshunov, Andrey, Northcott, Paul A., Zhan, Shing H., Mendez-Lago, Maria, Kool, Marcel, Jones, David T. W., Unterberger, Alexander, Morrissy, A. Sorana, Shih, David, Peacock, John, Ramaswamy, Vijay, Rolider, Adi, Wang, Xin, Witt, Hendrik, Hielscher, Thomas, Hawkins, Cynthia, Vibhakar, Rajeev, Croul, Sidney, Rutka, James T., Weiss, William A., Jones, Steven J. M., Eberhart, Charles G., Marra, Marco A., Pfister, Stefan M., Taylor, Michael D.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580007/
https://ncbi.nlm.nih.gov/pubmed/23184418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-012-1070-9
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