Vitamin and antioxidant rich diet increases MLH1 promoter DNA methylation in DMT2 subjects

BACKGROUND: Oxidative stress may lead to an increased level of unrepaired cellular DNA damage, which is discussed as one risk for tumor initiation. Mismatch repair (MMR) enzymes act as proofreading complexes that maintain the genomic integrity and MMR-deficient cells show an increased mutation rate....

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Main Authors: Switzeny, Olivier J, Müllner, Elisabeth, Wagner, Karl-Heinz, Brath, Helmut, Aumüller, Eva, Haslberger, Alexander G
格式: Artigo
語言:Inglês
出版: BioMed Central 2012
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579724/
https://ncbi.nlm.nih.gov/pubmed/23025454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1868-7083-4-19
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