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Vitamin and antioxidant rich diet increases MLH1 promoter DNA methylation in DMT2 subjects

BACKGROUND: Oxidative stress may lead to an increased level of unrepaired cellular DNA damage, which is discussed as one risk for tumor initiation. Mismatch repair (MMR) enzymes act as proofreading complexes that maintain the genomic integrity and MMR-deficient cells show an increased mutation rate....

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Bibliographic Details
Main Authors: Switzeny, Olivier J, Müllner, Elisabeth, Wagner, Karl-Heinz, Brath, Helmut, Aumüller, Eva, Haslberger, Alexander G
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579724/
https://ncbi.nlm.nih.gov/pubmed/23025454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1868-7083-4-19
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