Repurposing Itraconazole as a Treatment for Advanced Prostate Cancer: A Noncomparative Randomized Phase II Trial in Men With Metastatic Castration-Resistant Prostate Cancer

BACKGROUND. The antifungal drug itraconazole inhibits angiogenesis and Hedgehog signaling and delays tumor growth in murine prostate cancer xenograft models. We conducted a noncomparative, randomized, phase II study evaluating the antitumor efficacy of two doses of oral itraconazole in men with meta...

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Bibliographic Details
Main Authors: Antonarakis, Emmanuel S., Heath, Elisabeth I., Smith, David C., Rathkopf, Dana, Blackford, Amanda L., Danila, Daniel C., King, Serina, Frost, Anja, Ajiboye, A. Seun, Zhao, Ming, Mendonca, Janet, Kachhap, Sushant K., Rudek, Michelle A., Carducci, Michael A.
Format: Artigo
Language:Inglês
Published: AlphaMed Press 2013
Subjects:
Genitourinary Cancer: Prostate
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579600/
https://ncbi.nlm.nih.gov/pubmed/23340005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2012-314
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