Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials

BACKGROUND AND PURPOSE: Understanding drug effects on the heart is key to safety pharmacology assessment and anti-arrhythmic therapy development. Here our goal is to demonstrate the ability of computational models to simulate the effect of drug action on the electrical activity of the heart, at the...

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Detalhes bibliográficos
Principais autores: Zemzemi, Nejib, Bernabeu, Miguel O, Saiz, Javier, Cooper, Jonathan, Pathmanathan, Pras, Mirams, Gary R, Pitt-Francis, Joe, Rodriguez, Blanca
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579290/
https://ncbi.nlm.nih.gov/pubmed/22946617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02200.x
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