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FoxO3a Directs a Protective Autophagy Program in Hematopoietic Stem Cells
Blood production is ensured by rare self-renewing hematopoietic stem cells (HSCs). How HSCs accommodate the diverse cellular stresses associated with their life-long activity remains elusive. Here, we identify autophagy as an essential mechanism protecting HSCs from metabolic stress. We show that HS...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3579002/ https://ncbi.nlm.nih.gov/pubmed/23389440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11895 |
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