Glioma is formed by active Akt1 alone and promoted by active Rac1 in transgenic zebrafish

BACKGROUND: Ongoing characterization of glioma has revealed that Akt signaling plays a crucial role in gliomagenesis. In mouse models, however, Akt alone was not sufficient to induce glioma. METHODS: We established transgenic zebrafish that overexpressed dominant-active (DA) human Akt1 or Rac1(G12V)...

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Detalhes bibliográficos
Main Authors: Jung, In Hye, Leem, Ga Lam, Jung, Dawoon E., Kim, Min Hee, Kim, Eun Young, Kim, Se Hoon, Park, Hae-Chul, Park, Seung Woo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578497/
https://ncbi.nlm.nih.gov/pubmed/23325864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos387
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