Defective Retinal Vascular Endothelial Cell Development As a Consequence of Impaired Integrin αVβ8-Mediated Activation of Transforming Growth Factor-β

Deletions of the genes encoding the integrin αVβ8 (Itgav, Itgb8) have been shown to result in abnormal vascular development in the CNS, including prenatal and perinatal hemorrhage. Other work has indicated that a major function of this integrin in vivo is to promote TGFβ activation. In this paper, w...

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Detalhes bibliográficos
Main Authors: Arnold, Thomas D., Ferrero, Gina M., Qiu, Haiyan, Phan, Isabella T., Akhurst, Rosemary J., Huang, Eric J., Reichardt, Louis F.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578416/
https://ncbi.nlm.nih.gov/pubmed/22279205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5648-11.2012
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