Principles for understanding the accuracy of SHAPE-directed RNA structure modeling

Accurate RNA structure modeling is an important, incompletely solved, challenge. Single-nucleotide resolution SHAPE (selective 2'-hydroxyl acylation analyzed by primer extension) yields an experimental measurement of local nucleotide flexibility that can be incorporated as pseudo-free energy ch...

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Bibliografische gegevens
Hoofdauteurs: Leonard, Christopher W., Hajdin, Christine E., Karabiber, Fethullah, Mathews, David H., Favorov, Oleg, Dokholyan, Nikolay V., Weeks, Kevin M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578230/
https://ncbi.nlm.nih.gov/pubmed/23316814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300755u
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