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Manganese superoxide dismutase depletion in murine hematopoietic stem cells perturbs iron homeostasis, globin switching, and epigenetic control in erythrocyte precursor cells

Heme synthesis partially occurs in the mitochondrial matrix, thus there is a high probability that enzymes and intermediates important in the production of heme will be exposed to metabolic byproducts including reactive oxygen species. In addition, the need for ferrous iron for heme production, Fe-S...

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Bibliografski detalji
Glavni autori: Case, Adam J., Madsen, Joshua M., Motto, David G., Meyerholz, David K., Domann, Frederick E.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578015/
https://ncbi.nlm.nih.gov/pubmed/23219873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.11.018
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