Computational Analysis of KRAS Mutations: Implications for Different Effects on the KRAS p.G12D and p.G13D Mutations

BACKGROUND: The issue of whether patients diagnosed with metastatic colorectal cancer who harbor KRAS codon 13 mutations could benefit from the addition of anti-epidermal growth factor receptor therapy remains under debate. The aim of the current study was to perform computational analysis to invest...

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Detalhes bibliográficos
Main Authors: Chen, Chih-Chieh, Er, Tze-Kiong, Liu, Yen-Yi, Hwang, Jenn-Kang, Barrio, Maria Jesus, Rodrigo, Maximiliano, Garcia-Toro, Enrique, Herreros-Villanueva, Marta
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577811/
https://ncbi.nlm.nih.gov/pubmed/23437064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055793
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