Dysregulation of Protease and Protease Inhibitors in a Mouse Model of Human Pelvic Organ Prolapse

Mice deficient for the fibulin-5 gene (Fbln5(−/−)) develop pelvic organ prolapse (POP) due to compromised elastic fibers and upregulation of matrix metalloprotease (MMP)-9. Here, we used casein zymography, inhibitor profiling, affinity pull-down, and mass spectrometry to discover additional protease...

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Detalhes bibliográficos
Main Authors: Budatha, Madhusudhan, Silva, Simone, Montoya, Teodoro Ignacio, Suzuki, Ayako, Shah-Simpson, Sheena, Wieslander, Cecilia Karin, Yanagisawa, Masashi, Word, Ruth Ann, Yanagisawa, Hiromi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577807/
https://ncbi.nlm.nih.gov/pubmed/23437119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056376
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