Validation of an enzyme-linked immunosorbent assay for the quantification of human IgG directed against the repeat region of the circumsporozoite protein of the parasite Plasmodium falciparum

BACKGROUND: Several pre-erythrocytic malaria vaccines based on the circumsporozoite protein (CSP) antigen of Plasmodium falciparum are in clinical development. Vaccine immunogenicity is commonly evaluated by the determination of anti-CSP antibody levels using IgG-based assays, but no standard assay...

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Hoofdauteurs: Clement, Frederic, Dewar, Vincent, Van Braeckel, Eva, Desombere, Isabelle, Dewerchin, Marianne, Swysen, Christine, Demoitié, Marie-Ange, Jongert, Erik, Cohen, Joe, Leroux-Roels, Geert, Cambron, Pierre
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2012
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Methodology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577486/
https://ncbi.nlm.nih.gov/pubmed/23173602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-11-384
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