Hepatitis B virus X protein inhibits extracellular IFN-α-mediated signal transduction by downregulation of type I IFN receptor

We have previously shown that hepatitis B virus (HBV) protein X (HBX), a regulatory protein of HBV, activates Stat1, leading to type I interferon (IFN) production. Type I IFN secreted from HBX-expressing hepatic cells enforces antiviral signals through its binding to the cognate type I IFN receptor....

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Main Authors: CHO, IL-RAE, OH, MYUNGJU, KOH, SANG SEOK, MALILAS, WARAPORN, SRISUTTEE, RATAKORN, JHUN, BYUNG HAK, PELLEGRINI, SANDRA, FUCHS, SERGE Y., CHUNG, YOUNG-HWA
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577137/
https://ncbi.nlm.nih.gov/pubmed/22218495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2012.879
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