SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization

Steroid receptor coactivator 3 (SRC-3) is an oncogenic nuclear receptor coactivator that plays a significant role in drug resistance. Using a lentiviral cDNA library rescue screening approach, we identified a SRC-3 downstream gene—TRAF4 (tumor necrosis factor [TNF] receptor associated-factor 4)—that...

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Detalhes bibliográficos
Main Authors: Yi, Ping, Xia, Weiya, Wu, Ray-Chang, Lonard, David M., Hung, Mien-Chie, O'Malley, Bert W.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576513/
https://ncbi.nlm.nih.gov/pubmed/23388826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.203760.112
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