Morphological and Metabolic Changes in the Nigro-Striatal Pathway of Synthetic Proteasome Inhibitor (PSI)-Treated Rats: A MRI and MRS Study

Systemic administration of a Synthetic Proteasome Inihibitor (PSI) in rats has been described as able to provide a model of Parkinson’s disease (PD), characterized by behavioral and biochemical modifications, including loss of dopaminergic neurons in the substantia nigra (SN), as assessed by post-mo...

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Main Authors: Delli Pizzi, Stefano, Rossi, Cosmo, Di Matteo, Vincenzo, Esposito, Ennio, Guarnieri, Simone, Mariggiò, Maria Addolorata, Franciotti, Raffaella, Caulo, Massimo, Thomas, Astrid, Onofrj, Marco, Tartaro, Armando, Bonanni, Laura
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576393/
https://ncbi.nlm.nih.gov/pubmed/23431380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056501
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