SKLB023 Blocks Joint Inflammation and Cartilage Destruction in Arthritis Models via Suppression of Nuclear Factor-Kappa B Activation in Macrophage

Rheumatoid arthritis (RA) is the most common arthritis and is mainly characterized by symmetric polyarticular joint disorders. Our previous study demonstrated a novel small molecule compound (Z)-N-(3-Chlorophenyl)-2-(4-((2,4-dioxothiazolidin-5-ylidene) methyl) phenoxy) acet-amide (SKLB023) showed po...

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Bibliographic Details
Main Authors: Xie, Caifeng, Ma, Liang, Liu, Juan, Li, Xiuxia, Pei, Heying, Xiang, Mingli, Chen, Lijuan
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576337/
https://ncbi.nlm.nih.gov/pubmed/23431370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056349
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