Munc18-1 Protein Molecules Move between Membrane Molecular Depots Distinct from Vesicle Docking Sites

Four evolutionarily conserved proteins are required for mammalian regulated exocytosis: three SNARE proteins, syntaxin, SNAP-25, and synaptobrevin, and the SM protein, Munc18-1. Here, using single-molecule imaging, we measured the spatial distribution of large cohorts of single Munc18-1 molecules co...

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Main Authors: Smyth, Annya M., Yang, Lei, Martin, Kirsty J., Hamilton, Charlotte, Lu, Weiping, Cousin, Michael A., Rickman, Colin, Duncan, Rory R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Membrane Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576115/
https://ncbi.nlm.nih.gov/pubmed/23223447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.407585
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