2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Production of Reactive Oxygen Species Is An Essential Step in the Mechanism of Action to Accelerate Human Keratinocyte Differentiation

Chloracne is commonly observed in humans exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); yet, the mechanism of toxicity is not well understood. Using normal human epidermal keratinocytes, we investigated the mechanism of TCDD-mediated enhancement of epidermal differentiation by integrating fu...

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Detalhes bibliográficos
Main Authors: Kennedy, Lawrence H., Sutter, Carrie Hayes, Leon Carrion, Sandra, Tran, Quynh T., Bodreddigari, Sridevi, Kensicki, Elizabeth, Mohney, Robert P., Sutter, Thomas R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576006/
https://ncbi.nlm.nih.gov/pubmed/23152189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfs325
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