Modeling recent human evolution in mice by expression of a selected EDAR variant

An adaptive variant of the human Ectodysplasin receptor, EDARV370A, is one of the strongest candidates of recent positive selection from genome-wide scans. We have modeled EDAR370A in mice and characterized its phenotype and evolutionary origins in humans. Our computational analysis suggests the all...

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Detalhes bibliográficos
Main Authors: Kamberov, Yana G., Wang, Sijia, Tan, Jingze, Gerbault, Pascale, Wark, Abigail, Tan, Longzhi, Yang, Yajun, Li, Shilin, Tang, Kun, Chen, Hua, Powell, Adam, Itan, Yuval, Fuller, Dorian, Lohmueller, Jason, Mao, Junhao, Schachar, Asa, Paymer, Madeline, Hostetter, Elizabeth, Byrne, Elizabeth, Burnett, Melissa, McMahon, Andrew P., Thomas, Mark G., Lieberman, Daniel E., Jin, Li, Tabin, Clifford J., Morgan, Bruce A., Sabeti, Pardis C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575602/
https://ncbi.nlm.nih.gov/pubmed/23415220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.01.016
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