miR-21 Promotes Fibrogenic Epithelial-to-Mesenchymal Transition of Epicardial Mesothelial Cells Involving Programmed Cell Death 4 and Sprouty-1

The lining of the adult heart contains epicardial mesothelial cells (EMCs) that have the potential to undergo fibrogenic Epithelial-to-Mesenchymal Transition (EMT) during cardiac injury. EMT of EMCs has therefore been suggested to contribute to the heterogeneous fibroblast pool that mediates cardiac...

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Main Authors: Brønnum, Hasse, Andersen, Ditte C., Schneider, Mikael, Sandberg, Maria B., Eskildsen, Tilde, Nielsen, Solveig B., Kalluri, Raghu, Sheikh, Søren P.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575372/
https://ncbi.nlm.nih.gov/pubmed/23441172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056280
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