Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding

The activity of protein kinase B (Akt)—a major kinase promoting cell proliferation and survival—oscillates during the cell cycle. To investigate whether membrane phospholipids may regulate Akt phosphorylation and thus activity, we monitored the lipid profile of nocodazole-synchronized mouse NIH 3T3...

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Bibliografiske detaljer
Main Authors: Koeberle, Andreas, Shindou, Hideo, Koeberle, Solveigh C., Laufer, Stefan A., Shimizu, Takao, Werz, Oliver
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574958/
https://ncbi.nlm.nih.gov/pubmed/23359699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216182110
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