Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding

The activity of protein kinase B (Akt)—a major kinase promoting cell proliferation and survival—oscillates during the cell cycle. To investigate whether membrane phospholipids may regulate Akt phosphorylation and thus activity, we monitored the lipid profile of nocodazole-synchronized mouse NIH 3T3...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Koeberle, Andreas, Shindou, Hideo, Koeberle, Solveigh C., Laufer, Stefan A., Shimizu, Takao, Werz, Oliver
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2013
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574958/
https://ncbi.nlm.nih.gov/pubmed/23359699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216182110
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