A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen

BACKGROUND: Estrogen receptors alpha (ER) are implicated in many types of female cancers, and are the common target for anti-cancer therapy using selective estrogen receptor modulators (SERMs, such as tamoxifen). However, cell-type specific and patient-to-patient variability in response to SERMs (fr...

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Autores principales: Lebedeva, Galina, Yamaguchi, Azusa, Langdon, Simon P, Macleod, Kenneth, Harrison, David J
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3573949/
https://ncbi.nlm.nih.gov/pubmed/23134774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-6-138
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