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CENTRAL RHO KINASE INHIBITION RESTORES BAROREFLEX SENSITIVITY AND AT1R PROTEIN IMBALANCE IN CONSCIOUS RABBITS WITH CHRONIC HEART FAILURE
The small GTPase RhoA and its associated kinase ROCKII are involved in vascular smooth muscle cell contraction and endothelial nitric oxide synthase (eNOS) mRNA destabilization. Overactivation of the RhoA/ROCKII pathway is implicated in a number of pathologies including chronic heart failure (CHF) a...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3573242/ https://ncbi.nlm.nih.gov/pubmed/23283363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.111.00396 |
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