Dopamine-Mediated Oxidation of Methionine 127 in α-Synuclein Causes Cytotoxicity and Oligomerization of α-Synuclein

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the selective loss of dopaminergic neurons and the presence of Lewy bodies. Many recent studies focused on the interaction between α-synuclein (α-syn) and dopamine in the pathogenesis of PD, and fluorescent anisotropy sug...

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Main Authors: Nakaso, Kazuhiro, Tajima, Naoko, Ito, Satoru, Teraoka, Mari, Yamashita, Atsushi, Horikoshi, Yosuke, Kikuchi, Daisuke, Mochida, Shinsuke, Nakashima, Kenji, Matsura, Tatsuya
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3573015/
https://ncbi.nlm.nih.gov/pubmed/23457458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055068
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