Protein Kinase-C Beta Contributes to Impaired Endothelial Insulin Signaling in Humans with Diabetes Mellitus

BACKGROUND: Abnormal endothelial function promotes atherosclerotic vascular disease in diabetes. Experimental studies indicate that disruption of endothelial insulin signaling through the activity of protein kinase C-β (PKCβ) and nuclear factor κB (NFκB) reduces nitric oxide availability. We sought...

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Detalhes bibliográficos
Main Authors: Tabit, Corey E, Shenouda, Sherene M, Holbrook, Monica, Fetterman, Jessica L, Kiani, Soroosh, Frame, Alissa A, Kluge, Matthew A, Held, Aaron, Dohadwala, Mustali, Gokce, Noyan, Farb, Melissa, Rosenzweig, James, Ruderman, Neil, Vita, Joseph A, Hamburg, Naomi M
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572725/
https://ncbi.nlm.nih.gov/pubmed/23204109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.127514
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