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Gremlin induces cell proliferation and extra cellular matrix accumulation in mouse mesangial cells exposed to high glucose via the ERK1/2 pathway

BACKGROUND: Gremlin, a bone morphogenetic protein antagonist, plays an important role in the pathogenesis of diabetic nephropathy (DN). However, the specific molecular mechanism underlying Gremlin’s involvement in DN has not been fully elucidated. In the present study, we investigated the role of Gr...

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Autori principali: Huang, Haixia, Huang, Haiying, Li, Ying, Liu, Maodong, Shi, Yonghong, Chi, Yanqing, Zhang, Tao
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572428/
https://ncbi.nlm.nih.gov/pubmed/23394397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2369-14-33
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