Gremlin induces cell proliferation and extra cellular matrix accumulation in mouse mesangial cells exposed to high glucose via the ERK1/2 pathway

BACKGROUND: Gremlin, a bone morphogenetic protein antagonist, plays an important role in the pathogenesis of diabetic nephropathy (DN). However, the specific molecular mechanism underlying Gremlin’s involvement in DN has not been fully elucidated. In the present study, we investigated the role of Gr...

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Detalhes bibliográficos
Main Authors: Huang, Haixia, Huang, Haiying, Li, Ying, Liu, Maodong, Shi, Yonghong, Chi, Yanqing, Zhang, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572428/
https://ncbi.nlm.nih.gov/pubmed/23394397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2369-14-33
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