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p53 restoration kills primitive leukemia cells in vivo and increases survival of leukemic mice

Loss of p53 function is a common feature of human cancers and it is required for differentiated tumor cell maintenance; however, it is not known whether sustained inactivation of the p53 pathway is needed for cancer stem cell persistence. Chronic myeloid leukemia (CML) is caused by a chromosome tran...

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Main Authors: Velasco-Hernández, Talía, Vicente-Dueñas, Carolina, Sánchez-García, Isidro, Martin-Zanca, Dionisio
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570500/
https://ncbi.nlm.nih.gov/pubmed/23255106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.23031
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